2D-QSAR Studies of Some N-((1H-Benzo[d] Imidazol-1-yl) (Phenyl) Methylene) Benzenamine Analogues As Antifungal Activity
نویسندگان
چکیده
In the present study quantitative structure activity relationship studies were performed on a series of N-{(1H-Benzo[d] Imidazol-1-yl) (Phenyl) Methylene} Benzenamine analogues as antifungal activity using Chem Office ultra 8.0.3. Multiple linear regression analysis was performed to derive quantitative structure activity relationship models which were further evaluated internally as well as externally for the prediction of activity. This study indicates that thermodynamic descriptors Molar refractivity, ovality, log P play important role for the antifungal activity. The information generated from the present study may be useful in the design of more potent substituted compounds N-{(1H-Benzo [d] Imidazol-1-yl) (Phenyl) Methylene} Benzenamine analogues as antifungal activity.
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